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Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Gene Name: | lysine (K)-specific demethylase 8 |
Synonyms: | KDM8, FLJ13798, JMJD5, Jumonji domain containing 5, Lysine-specific demethylase 8 |
Target Sequences: | NM_024773 NP_079049.2 Q8N371 |
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