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Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
Gene Name: | Bartter syndrome, infantile, with sensorineural deafness (Barttin) |
Synonyms: | BSND, BART, Barttin, DFNB73 |
Target Sequences: | NM_057176 NP_476517.1 Q8WZ55 |
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