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CCL23 / MIP3 is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms.
Gene Name: | chemokine (C-C motif) ligand 23 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL23, C-C motif chemokine 23, C6 beta-chemokine, CK-BETA-8, Ckb-8, CKb8, Ckb-8-1, Hmrp-2a, MIP-3, MPIF1, MPIF-1, SCYA23, MIP3, Small-inducible cytokine A23 |
Target Sequences: | NM_005064 NP_005055.3 P55773 |
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