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Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Gene Name: | Rap guanine nucleotide exchange factor (GEF) 3 |
Synonyms: | RAPGEF3, Bcm910, CAMP-GEFI, CGEF1, HSU79275, EPAC, EPAC 1, EPAC1 |
Target Sequences: | NM_006105 NP_006096.2 O95398 |
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