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E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
Gene Name: | tripartite motif containing 27 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM27, Ret finger protein, Tripartite motif-containing 27, Zinc finger protein RFP, RFP transforming protein, RING finger protein 76, RNF76, Tripartite motif containing 27, RFP |
Target Sequences: | NM_006510 NP_006501.1 P14373 |
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