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Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Gene Name: | MAS1 oncogene |
Family/Subfamily: | GPCR , Orphan-A |
Synonyms: | MAS1, Mas proto-oncogene, Proto-oncogene Mas, MAS, MAS1 oncogene |
Target Sequences: | NM_002377 NP_002368.1 P04201 |
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