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Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Gene Name: | epidermal growth factor receptor pathway substrate 15 |
Synonyms: | EPS15, AF-1P, AF1P, MLLT5, Protein AF-1p, Protein Eps15 |
Target Sequences: | NM_001981 NP_001972.1 P42566 |
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