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Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells.
Gene Name: | iroquois homeobox 3 |
Synonyms: | IRX3, Homeodomain protein IRXB1, IRXB1, Iroquois homeobox 3, Iroquois homeobox protein 3, IRX-1 |
Target Sequences: | NM_024336 P78415 P78415 |
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