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PDLIM7 / Enigma is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.
Gene Name: | PDZ and LIM domain 7 (enigma) |
Synonyms: | PDLIM7, ENIGMA, LMP1, Lim mineralization protein 3, PDZ and LIM domain 7 (enigma), Protein enigma, LIM domain protein, LMP, PDZ and LIM domain protein 7, LIM mineralization protein, LMP3 |
Target Sequences: | NM_005451 NP_005442.2 Q9NR12 |
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