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MUC20 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.
Gene Name: | Mucin 20, Cell Surface Associated |
Synonyms: | MUC20, KIAA1359, Mucin-20, Transmembrane mucin MUC20S, MUC-20 |
Target Sequences: | AA101929 |
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