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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Gene Name: | dynein, cytoplasmic 1, intermediate chain 2 |
Synonyms: | DYNC1I2, DNCI2, DNCIC2, DH IC-2, IC2 |
Target Sequences: | AK055491 BAB70932.1 Q13409 |
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