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Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Gene Name: | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
Synonyms: | CCNB1IP1, C14orf18, HEI10, Human enhancer of invasion 10 |
Target Sequences: | NM_021178 NP_067001.3 Q9NPC3 |
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