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ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
Synonyms: | ASPM, Asp homolog, Calmbp1, MCPH5, ASP |
Target Sequences: | NM_018136 BAA91676.1 Q8IZT6 |
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