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E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Gene Name: | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase |
Synonyms: | SHPRH, BA545I5.2, KIAA2023 |
Target Sequences: | AA476814 NP_775105.1 Q149N8 |
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