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PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Gene Name: | protein phosphatase 1, regulatory subunit 13B |
Synonyms: | PPP1R13B, ASPP1, p53BP2-like, p85, KIAA0771 |
Target Sequences: | NM_015316 NP_056131.2 Q96KQ4 |
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