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FBXO7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
Gene Name: | F-box protein 7 |
Family/Subfamily: | F-Box |
Synonyms: | FBXO7, F-box protein 7, FBX7, FBX07, PARK15, PKPS, F-box only protein 7, FBX |
Target Sequences: | NM_012179 NP_036311.3 Q9Y3I1 |
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