Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
Gene Name: | retinoblastoma binding protein 8 |
Synonyms: | RBBP8, CTIP, DNA endonuclease RBBP8, RIM, SAE2, COM1, CtBP-interacting protein, JWDS, RBBP-8, SCKL2, Seckel syndrome 2 |
Target Sequences: | NM_002894 NP_002885.1 Q99708 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.