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CLP / COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
Gene Name: | coactosin-like 1 (Dictyostelium) |
Synonyms: | COTL1, CLP, Coactosin-like protein |
Target Sequences: | NM_021149 NP_066972.1 Q14019 |
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