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DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
Gene Name: | INO80 complex subunit |
Synonyms: | INO80, Homolog of yeast INO80, INO80 homolog (S. cerevisiae), INO80A, INO80 complex subunit A, KIAA1259, DNA helicase INO80, HINO80, INOC1 |
Target Sequences: | AK002176 BAA92122.1 Q9ULG1 |
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