Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
SIII / TCEB1 is the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Gene Name: | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) |
Synonyms: | TCEB1, Elongin 15 kDa subunit, EloC, SIII, SIII p15, Elongin-C |
Target Sequences: | NM_005648 NP_005639.1 Q15369 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.