Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
TAPBP / Tapasin is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Gene Name: | TAP binding protein (tapasin) |
Synonyms: | TAPBP, TAP binding protein (tapasin), TAPA, TAP-associated protein, TAP-binding protein, TPN, NGS17, NGS-17, Tapasin, TPSN |
Target Sequences: | NM_003190 NP_003181.3 O15533 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.