TAOK1 / TAO1

TAO kinase 1

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TAOK1 / TAO1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human TAOK1 / TAO1 Protein (Recombinant GST, N-terminus) (aa892-1001) - LS-G62972

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TAOK1 / TAO1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92229

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.1 kDa

Price:

20 µg/$215

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TAOK1 / TAO1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110988

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.1 kDa

Price:

100 µg/$710

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