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TAOK1 / TAO1
TAO kinase 1
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
| Gene Name: | TAO kinase 1 |
| Family/Subfamily: | Protein Kinase , TAO |
| Synonyms: | TAOK1, MAP3K16, MARK Kinase, HKFC-B, KFC-B, TAO kinase 1, TAO1, MARKK, PSK2, HTAOK1, KIAA1361, Kinase from chicken homolog B, PSK-2, Rat TAO1, STE20-like kinase PSK2, Sulu3 |
| Target Sequences: | NM_020791 NP_065842.1 Q7L7X3 |
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