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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Gene Name: | transaldolase 1 |
Synonyms: | TALDO1, Dihydroxyacetone transferase, Glycerone transferase, TALDO, TALH, Transaldolase, TAL-H, TAL, TALDOR, Transaldolase 1 |
Target Sequences: | NM_006755 NP_006746.1 P37837 |
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