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TACR1 / NK1R

tachykinin receptor 1

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing.

Gene Name:	tachykinin receptor 1
Family/Subfamily:	GPCR , Tachykinin
Synonyms:	TACR1, Neurokinin receptor 1, NK-1R, Nk1 tachykinin receptor, NK1R, TAC1R, Tachykinin 1 receptor, NKIR, Substance-P receptor, Neurokinin 1 receptor, NK-1 receptor, Tachykinin receptor 1
Target Sequences:	NM_001058 NP_001049.1 P25103

Publications (22)

Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception. Anderson LE, Seybold VS. Neuroscience letters. 2000 283:29-32. [PubMed:10729626]

Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex. Tooney PA, Au GG, Chahl LA. Neuroscience letters. 2000 283:185-8. (IHC; Human) [PubMed:10754218]

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Setou M, Nakagawa T, Seog DH, Hirokawa N. Science (New York, N.Y.). 2000 288:1796-802. [PubMed:10846156]

Localization of NK1 and NK3 receptors in guinea-pig brain. Yip J, Chahl LA. Regulatory peptides. 2001 98:55-62. [PubMed:11179779]

Increased tachykinin NK(1) receptor immunoreactivity in the prefrontal cortex in schizophrenia. Tooney PA, Crawter VC, Chahl LA. Biological psychiatry. 2001 49:523-7. (IHC; Human) [PubMed:11257237]

NK-1 receptor gene expression is related to pain in chronic pancreatitis. Shrikhande SV, Friess H, di Mola FF, Tempia-Caliera A, Conejo Garcia JR, Zhu Z, Zimmermann A, Bchler MW. Pain. 2001 91:209-17. (IHC; Human) [PubMed:11275376]

Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct. Ma MC, Huang HS, Chien CT, Wu MS, Chen CF. American journal of physiology. Renal physiology. 2002 283:F164-72. [PubMed:12060598]

The expression of neurokinin-1 receptor at striatal and pallidal levels in normal human brain. Mounir S, Parent A. Neuroscience research. 2002 44:71-81. [PubMed:12204295]

Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites. Kc P, Haxhiu MA, Tolentino-Silva FP, Wu M, Trouth CO, Mack SO. Respiratory Physiology & Neurobiology. 2002 133:75-88. [PubMed:12385733]

A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Commons KG, Connolley KR, Valentino RJ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 28:206-15. [PubMed:12589373]

Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy. Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Brain : a journal of neurology. 2003 126:2183-90. (IHC; Human) [PubMed:12902309]

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:7771-6. (ICC; Human) [PubMed:16675550] [PMC:PMC1457089]

Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats. Broccardo M, Linari G, Agostini S, Amadoro G, Carpino F, Ciotti MT, Petrella C, Petrozza V, Severini C, Improta G. American journal of physiology. Gastrointestinal and liver physiology. 2006 291:G518-24. [PubMed:16782701]

Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. Fong AY, Potts JT. The Journal of physiology. 2006 575:869-85. (IHC; Rat) [PubMed:16825299] [PMC:PMC1995693]

Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Hazlett LD, McClellan SA, Barrett RP, Liu J, Zhang Y, Lighvani S. Investigative ophthalmology & visual science. 2007 48:797-807. (IHC; Mouse) [PubMed:17251480]

cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Schmidtko A, Gao W, Knig P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:8568-76. (IHC; Mouse) [PubMed:18716216]

Cardiac damage after lesions of the nucleus tractus solitarii. Nayate A, Moore SA, Weiss R, Taktakishvili OM, Lin LH, Talman WT. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 296:R272-9. (IHC; Rat) [PubMed:19020288] [PMC:PMC2643979]

Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis. Caioli S, Curcio L, Pieri M, Antonini A, Marolda R, Severini C, Zona C. Neurobiology of disease. 2011 44:92-101. [PubMed:21726643]

Kinetics of neuronal contribution during the development of a contact allergic reaction. Altawil R, Lystrm J, El-Nour H. Archives of dermatological research. 2012 304:273-81. (IHC; Human) [PubMed:22198823]

Substance P alterations in skin and brain of chronically stressed atopic-like mice. Grip L, Lonne-Rahm SB, Holst M, Johansson B, Nordlind K, Theodorsson E, El-Nour H. Journal of the European Academy of Dermatology and Venereology : JEADV. 2013 27:199-205. (ICC, IHC; Mouse) [PubMed:22251186]

Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation. Humes DJ, Simpson J, Smith J, Sutton P, Zaitoun A, Bush D, Bennett A, Scholefield JH, Spiller RC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2012 24:318-e163. (IHC; Human) [PubMed:22276853]

Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Talman WT, Dragon DN, Jones SY, Moore SA, Lin LH. Cellular and molecular neurobiology. 2012 32:1119-26. (ICC, IHC-Fr; Rat) [PubMed:22484855]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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