TAB2

TGF-beta activated kinase 1/MAP3K7 binding protein 2

TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TAB2 (3)

Publications

No (3)

Tag

10His, N-terminus + Myc, C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

Baculovirus (1)

HEK 293 Cells (1)

Purification

Purified (1)

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TAB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101291

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.3 kDa

Price:

100 µg/$494

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Human TAB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85316

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.3 kDa

Price:

20 µg/$150

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Human TAB2 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G136888

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

37.1 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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