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SYT1 / Synaptotagmin

synaptotagmin I

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.

Gene Name: synaptotagmin I
Family/Subfamily: Synaptotagmin , Not assigned-Other
Synonyms: SYT1, SYT, SVP65, Synaptotagmin, Synaptotagmin 1, SytI, Synaptotagmin I, Synaptotagmin-1
Target Sequences: NM_005639 NP_005630.1 P21579

Publications (2)

1
Eyes shut homolog (EYS) interacts with matriglycan of O-mannosyl glycans whose deficiency results in EYS mislocalization and degeneration of photoreceptors. Yu Liu , Miao Yu , Xuanze Shang, My Hong Hoai Nguyen, Shanmuganathan Balakrishnan, Rachel Sager, Huaiyu Hu. Scientific reports. 2020 May;10:7795. [Full Text Article] [PubMed:32385361] [PMC:PMC7210881] Related Antibodies: LS-B5899.
2
16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis. Danielle L Tomasello, Jiyoon L Kim, Yara Khodour, Jasmine M McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H Futerman, Hazel Sive. iScience. 2022 January;25:103551. [Full Text Article] [PubMed:34984324] [PMC:PMC8693007] Related Antibodies: LS-B12889.

☰ Filters
Products
Proteins (13)
Over-Expression Lysate (6)
Recombinant (7)
SYT1 / Synaptotagmin (13)
No (13)
GST (1)
His (2)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (10)
293T Cells (3)
E. coli (3)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (3)
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
SYT1 / Synaptotagmin Protein - Recombinant Synaptotagmin I By SDS-PAGE
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E. coli
His-T7
36.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
SYT1 / Synaptotagmin Protein - 12.5% SDS-PAGE of human SYT1 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.16 kDa
10 µg/$479; 25 µg/$670
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
Select
E. coli
His
40.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
SYT1 / Synaptotagmin Protein
Select
E. coli
His
10 µg/$361; 50 µg/$739
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).