SYNE2 / Nesprin-2

Spectrin Repeat Containing, Nuclear Envelope 2

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.

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Products

ELISA Kits (1)

Type

Sandwich (1)

Target

SYNE2 / Nesprin-2 (1)

Reactivity

Human (1)

Format

96-Well Strip Plate (1)

Publications

No (1)

Sample Type

Tissue Homogenates (1)

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Human SYNE2 / Nesprin-2 (Sandwich ELISA) ELISA Kit - LS-F8315

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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