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SYNCRIP / HnRNP Q

synaptotagmin binding, cytoplasmic RNA interacting protein

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Gene Name: synaptotagmin binding, cytoplasmic RNA interacting protein
Synonyms: SYNCRIP, DJ3J17.2, GRYRBP, HnRNP-Q, HNRPQ, HNRPQ1, HnRNP Q, NS1-associated protein 1, NSAP1, GRY-RBP, PP68
Target Sequences: NM_006372 NP_006363.4 O60506

Publications (1)

1
Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. Wongpalee SP, Vashisht A, Sharma S, Chui D, Wohlschlegel JA, Black DL. eLife. 2016 5: (WB; Human) [Full Text Article] [PubMed:27882870] [PMC:PMC5122456] Related Antibodies: LS-C31342.

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Proteins (13)
Over-Expression Lysate (10)
Recombinant (3)
SYNCRIP / HnRNP Q (13)
No (13)
GST (3)
Myc-DDK (Flag) (10)
Human (8)
293T Cells (5)
E. coli (1)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (2)
SYNCRIP / HnRNP Q Protein - 12.5% SDS-PAGE of human SYNCRIP stained with Coomassie Blue
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Wheat Germ Extract
GST
83.49 kDa
2 µg/$439
SYNCRIP / HnRNP Q Protein - 12.5% SDS-PAGE of human SYNCRIP stained with Coomassie Blue
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Wheat Germ Extract
GST
72.7 kDa
2 µg/$439
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.3 kDa
20 µg/$150
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
62.5 kDa
20 µg/$150
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$150
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
65.5 kDa
20 µg/$150
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
69.4 kDa
20 µg/$215
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
62.3 kDa
100 µg/$494
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
62.5 kDa
100 µg/$494
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
100 µg/$494
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
65.5 kDa
100 µg/$494
SYNCRIP / HnRNP Q Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
69.4 kDa
100 µg/$710
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E. coli
GST
48.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).