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Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Gene Name: | SWAP switching B-cell complex 70kDa subunit |
Synonyms: | SWAP70, KIAA0640, HSPC321, SWAP-70, Switch-associated protein 70 |
Target Sequences: | NM_015055 NP_055870.2 Q9UH65 |
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