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Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Gene Name: | SUZ12 polycomb repressive complex 2 subunit |
Synonyms: | SUZ12, ChET 9 protein, Joined to JAZF1 protein, CHET9, JJAZ1, KIAA0160, Polycomb protein SUZ12 |
Target Sequences: | NM_015355 NP_056170.2 Q15022 |
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