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Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
Gene Name: | suppressor of variegation 4-20 homolog 1 (Drosophila) |
Synonyms: | SUV420H1, CGI-85, CGI85, KMT5B, Lysine N-methyltransferase 5B, Su(var)4-20 homolog 1, Suv4-20h1 |
Target Sequences: | NM_017635 NP_060105.3 Q4FZB7 |
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