order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
SUPT4H1 / SPT4
suppressor of Ty 4 homolog 1 (S. cerevisiae)
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
| Gene Name: | suppressor of Ty 4 homolog 1 (S. cerevisiae) |
| Synonyms: | SUPT4H1, DSIF p14, SPT4, SPT4H, SUPT4H, DSIF small subunit, HSPT4 |
| Target Sequences: | NM_003168 NP_003159.1 P63272 |
![SUPT4H1 / SPT4 Antibody - Immunofluorescence of monoclonal antibody to SUPT4H1 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/supt4h1-spt4-antibody-clone-3g4-ls-c198288/146698_5237859.jpg)
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
