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SUMO1 / SMT3
small ubiquitin-like modifier 1
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.
| Gene Name: | small ubiquitin-like modifier 1 |
| Synonyms: | SUMO1, GAP modifying protein 1, GMP1, OFC10, Sentrin, SMT3 homolog 3, SMT3C, SMT3H3, SUMO-1, Ubiquitin-like protein UBL1, PIC1, Ubiquitin-like 1 (sentrin), UBL1, DAP1, GAP-modifying protein 1, Ubiquitin-like protein SMT3C |
| Target Sequences: | NM_003352 NP_003343.1 P63165 |
Publications (4)
1
SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. The Journal of biological chemistry. 2005 280:24330-8.
[PubMed:15857832]
Related Antibodies: LS-C161612.
2
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A. Human molecular genetics. 2010 19:181-95.
[PubMed:19843541]
3
Insights into high affinity small ubiquitin-like modifier (SUMO) recognition by SUMO-interacting motifs (SIMs) revealed by a combination of NMR and peptide array analysis. Namanja AT, Li YJ, Su Y, Wong S, Lu J, Colson LT, Wu C, Li SS, Chen Y. The Journal of biological chemistry. 2012 287:3231-40.
[PubMed:22147707]
[PMC:PMC3270977]
Related Antibodies: LS-C96460.
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SUMO1 / SMT3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
SUMO1 / SMT3 Rabbit anti-Human Polyclonal Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (aa55-86) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SUMO1 / SMT3 Mouse anti-Human Monoclonal (66AT1273.94) Antibody
Human
WB
Unconjugated
400 µl/$393
SUMO1 / SMT3 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$786
SUMO1 / SMT3 Mouse anti-Human Monoclonal (SM1/495) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Ready-to-Use) (SM1/495) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SM1/495) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SUMO1 / SMT3 Mouse anti-Human Monoclonal (5B12) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
100 µg/$413
SUMO1 / SMT3 Mouse anti-Human Monoclonal (SUMO1/1188) Antibody
Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SUMO1/1188) Antibody
Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Ready-to-Use) (SUMO1/1188) Antibody
Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (S1MT-2) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Ready-to-Use) (S1MT-2) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
SUMO1 / SMT3 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (S1MT-2) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (aa55-86) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (aa55-86) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SUMO1 / SMT3 Rabbit anti-Human Polyclonal (aa55-86) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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