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Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
Gene Name: | sulfatase 1 |
Synonyms: | SULF1, Extracellular sulfatase Sulf-1, HSULF-1, KIAA1077, Sulfatase FP, SULF-1, Sulfatase 1 |
Target Sequences: | AB029000 BAA83029.1 Q8IWU6 |
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