STUB1 / CHIP

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

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Products

ELISA Kits (9)

Type

Custom (3)

Sandwich (6)

Target

STUB1 / CHIP (9)

Reactivity

Human (4)

Mouse (4)

Chicken (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (8)

Publications

No (9)

Sample Type

Plasma (5)

Serum (5)

Tissue Homogenates (3)

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Human STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F38163

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F35990

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Chicken STUB1 / CHIP (Custom) ELISA Kit - LS-F66414

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Price:

1 Plate/$783

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Mouse STUB1 / CHIP (Custom) ELISA Kit - LS-F65757

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$669

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Human STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F66770

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F9065

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$811

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Mouse STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F35991

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F38479

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human STUB1 / CHIP (Custom ELISA) ELISA Kit - LS-F50278

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$635

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