STUB1 / CHIP

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

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Products

Antibodies (43)

ELISA Kits (9)

Proteins (8)

Type

Custom (3)

Over-Expression Lysate (2)

Primary (43)

Recombinant (6)

Sandwich (6)

Target

STUB1 / CHIP (60)

Reactivity

Human (47)

Mouse (22)

Rat (13)

Bat (7)

Bovine (4)

Chicken (5)

Chimpanzee (6)

Dog (5)

Gibbon (6)

Guinea pig (6)

Hamster (1)

Horse (4)

Monkey (8)

Pig (4)

Xenopus (4)

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Application

IHC (12)

IHC-P (10)

WB (34)

Flo (7)

ELISA (19)

IF (3)

IP (4)

Peptide-ELISA (2)

Host

rabbit (38)

mouse (2)

goat (3)

Product Group

IHCPlus (5)

Isotype

IgG (27)

IgG1,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (41)

Clone

1008CT12.4.1 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (8)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Preservative Free (1)

Unconjugated (29)

Epitope

aa236-263 (7)

N-Terminus (5)

aa218-267 (4)

C-Terminus (2)

aa253-303 (2)

aa1-50 (1)

aa203-231 (1)

aa219-231 (1)

Publications

No (60)

Sample Type

Plasma (5)

Serum (5)

Tissue Homogenates (3)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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IHC-plus™ STUB1 / CHIP Antibody (aa219-231) LS-B6443

(4.0) Rating

Antibody:

STUB1 / CHIP Goat anti-Human Polyclonal (aa219-231) Antibody

Reactivity:

Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Mouse, Dog, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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STUB1 / CHIP Antibody LS-C502171

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IHC-plus™ STUB1 / CHIP Antibody LS-B10877

(4.0) Rating

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Human STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F38163

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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STUB1 / CHIP Antibody (aa1-50) LS-C288366

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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STUB1 / CHIP Antibody (C-Terminus, clone 1008CT12.4.1) LS-C757664

Antibody:

STUB1 / CHIP Mouse anti-Human Monoclonal (C-Terminus) (1008CT12.4.1) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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STUB1 / CHIP Antibody (aa203-231) LS-C99207

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa203-231) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ STUB1 / CHIP Antibody (aa253-303) LS-B11048

(4.0) Rating

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa253-303) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$485

Select

IHC-plus™ STUB1 / CHIP Antibody (aa253-303) LS-B11567

(4.0) Rating

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa253-303) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$485

Select

STUB1 / CHIP Antibody LS-C662711

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

IHC-plus™ STUB1 / CHIP Antibody LS-B17017

(4.0) Rating

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

STUB1 / CHIP Antibody LS-C806094

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Human STUB1 / CHIP (Sandwich ELISA) ELISA Kit - LS-F35990

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

STUB1 / CHIP Antibody LS-C754019

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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STUB1 / CHIP Antibody (aa236-263) LS-C330185

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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STUB1 / CHIP Antibody (aa236-263, Biotin) LS-C241389

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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STUB1 / CHIP Antibody (aa236-263, FITC) LS-C241392

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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STUB1 / CHIP Antibody (aa236-263, Azide-free, HRP) LS-C248277

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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STUB1 / CHIP Antibody (aa236-263, APC) LS-C241388

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

STUB1 / CHIP Antibody (aa236-263, PE) LS-C241395

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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STUB1 / CHIP Antibody (N-Terminus) LS-C144973

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

Select

STUB1 / CHIP Antibody LS-C489317

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

STUB1 / CHIP Antibody LS-C489316

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

STUB1 / CHIP Antibody (aa236-263) LS-C161582

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal (aa236-263) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

STUB1 / CHIP Antibody LS-C489315

Antibody:

STUB1 / CHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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