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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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STK24 / MST3
serine/threonine kinase 24
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
| Gene Name: | serine/threonine kinase 24 |
| Family/Subfamily: | Protein Kinase , YSK |
| Synonyms: | STK24, MST-3, MST3, Serine/threonine kinase 24, STE20-like kinase 3, STE20-like kinase MST3, MST3B, STE20, Sterile 20-like kinase 3 |
| Target Sequences: | NM_003576 NP_003567.2 Q9Y6E0 |
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