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Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Gene Name: | serine/threonine kinase 10 |
Family/Subfamily: | Protein Kinase , SLK |
Synonyms: | STK10, LOK, PRO2729, Serine/threonine kinase 10, Lymphocyte-oriented kinase |
Target Sequences: | NM_005990 NP_005981.3 O94804 |
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