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STAT6

signal transducer and activator of transcription 6, interleukin-4 induced

STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Gene Name: signal transducer and activator of transcription 6, interleukin-4 induced
Synonyms: STAT6, D12S1644, IL-4-STAT, Stat-6, STAT6B, STAT6C, STAT, interleukin4-induced, IL-4 Stat, Transcription factor IL-4 STAT
Target Sequences: NM_003153 NP_003144.3 P42226

Publications (2)

1
CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma. Sarah Svenningsen, Ehsan Haider, Colm Boylan, Manali Mukherjee, Rachel L Eddy, Dante P I Capaldi, Grace Parraga, Parameswaran Nair. Chest. 2019 Jun;155:1178-1189. [Full Text Article] [PubMed:30910637]
2
PARP14 is a novel target in STAT6 mutant follicular lymphoma. Michael Mentz, William Keay, Carolin Dorothea Strobl, Martina Antoniolli, Louisa Adolph, Michael Heide, Axel Lechner, Sarah Haebe, Elisa Osterode, Robert Kridel, Christoph Ziegenhain, Lucas Esteban Wange, Johannes Adrian Hildebrand, Tanaya Shree, Elisabeth Silkenstedt, Annette M Staiger, German Ott, Heike Horn, Monika Szczepanowski, Julia Richter, Ronald Levy, Andreas Rosenwald, Wolfgang Enard, Ursula Zimber-Strobl, Michael von Bergwelt-Baildon, Wolfgang Hiddemann, Wolfram Klapper, Marc Schmidt-. Leukemia. 2022 September;36:2281-2292. [Full Text Article] [PubMed:35851155] [PMC:PMC9417990] Related Antibodies: LS-B6154.

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Products
ELISA Kits (16)
Cell-Based Phosphorylation (3)
Competitive EIA (1)
Custom (1)
Sandwich (11)
STAT6 (16)
Human (7)
Mouse (6)
Rat (3)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
96-Well Microplate (3)
96-Well Strip Plate (13)
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Yes (1)
Adherent Cell Cultures (3)
Plasma (6)
Serum (6)
Tissue Homogenates (3)
STAT6 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$641
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$798
STAT6 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
STAT6 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$505
STAT6 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
STAT6 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
STAT6 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
STAT6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).