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STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Gene Name: | signal transducer and activator of transcription 6, interleukin-4 induced |
Synonyms: | STAT6, D12S1644, IL-4-STAT, Stat-6, STAT6B, STAT6C, STAT, interleukin4-induced, IL-4 Stat, Transcription factor IL-4 STAT |
Target Sequences: | NM_003153 NP_003144.3 P42226 |
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