STAT1

signal transducer and activator of transcription 1, 91kDa

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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Products

Proteins (16)

Type

Over-Expression Lysate (6)

Recombinant (10)

Target

STAT1 (16)

Publications

No (16)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (8)

Species

Human (12)

Mouse (1)

Source

293T Cells (3)

Baculovirus (1)

E. coli (5)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human STAT1 Protein (Recombinant His) - LS-G922

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human STAT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66963

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

20 µg/$1,107

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Mouse STAT1 Protein (Recombinant His, N-Terminal) (aa432-680) - LS-G24451

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human STAT1 Protein (Recombinant His-T7) (aa343-602) - LS-G24450

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human STAT1 Protein (Recombinant GST) (Full Length) - LS-G30568

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

109.4 kDa

Price:

2 µg/$439

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Human STAT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66962

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.2 kDa

Price:

20 µg/$1,107

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Human STAT1 Protein (Recombinant GST, N-terminus) (aa613-712) - LS-G60226

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78819

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.2 kDa

Price:

20 µg/$215

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Human STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78820

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

20 µg/$150

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Human STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78821

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.2 kDa

Price:

20 µg/$215

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STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127023

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.2 kDa

Price:

100 µg/$710

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Human STAT1 Protein (Recombinant His-GST) (Met1-Val712) - LS-G97922

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

111 kDa

Price:

100 µg/$721

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STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107039

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

100 µg/$494

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STAT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114708

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.2 kDa

Price:

100 µg/$710

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Human STAT1 Protein (Recombinant) (Met1-Val712) - LS-G139753

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human STAT1 Protein (Recombinant) (Met1-Val712) - LS-G39640

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,680; 1 mg/$2,353

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