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Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Gene Name: | tripartite motif containing 22 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM22, GPSTAF50, RNF94, Staf-50, Tripartite motif containing 22, STAF50, Tripartite motif-containing 22, RING finger protein 94, Tripartite binding motif 22 |
Target Sequences: | NM_006074 NP_006065.2 Q8IYM9 |
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