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Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).
Gene Name: | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide Alpha-2,6-sialyltransferase 1 |
Synonyms: | ST6GALNAC1, SIAT7A, Sialyltransferase 7A, ST6GalNAcI, STYI, HSY11339, SIAT7-A, ST6GalNAc I |
Target Sequences: | NM_018414 NP_060884.1 |
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