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SSTR2
somatostatin receptor 2
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
| Gene Name: | somatostatin receptor 2 |
| Family/Subfamily: | GPCR , Somatostatin |
| Synonyms: | SSTR2, Somatostatin receptor 2, SS2R, SST2, Somatostatin receptor II, SRIF-1, Somatostatin receptor type 2, SS-2-R, SS2-R, SSTR2A, Somatostatin receptor 2a |
| Target Sequences: | NM_001050 NP_001041.1 P30874 |
Publications (8)
1
Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody. Dournaud P, Gu YZ, Schonbrunn A, Mazella J, Tannenbaum GS, Beaudet A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 16:4468-78. (ICC, WB; Rat)
[PubMed:8699257]
2
Coupling specificity between somatostatin receptor sst2A and G proteins: isolation of the receptor-G protein complex with a receptor antibody. Gu YZ, Schonbrunn A. Molecular endocrinology (Baltimore, Md.). 1997 11:527-37. (IP; Rat)
[PubMed:9139797]
3
Immunohistochemical localization of somatostatin receptors sst2A in human tumors. Reubi JC, Kappeler A, Waser B, Laissue J, Hipkin RW, Schonbrunn A. The American journal of pathology. 1998 153:233-45. (WB, IHC-P, IHC-Fr; Human)
[PubMed:9665484]
[PMC:PMC1852945]
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Fast Shipping
SSTR2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Cancer Pathology
Fast Shipping
SSTR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
SSTR2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
SSTR2 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IHC-P
Unconjugated
100 µg/$941
SSTR2 Mouse anti-Human Monoclonal (6A1C6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-Fr, IP, WB
Unconjugated
0.1 ml/$386
SSTR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
SSTR2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
SSTR2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
SSTR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$649
293T Cells
Myc-DDK (Flag)
41.2 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SSTR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
SSTR2 Mouse anti-Human Monoclonal (6H9D2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$459
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
100 µl/$755
SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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