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SRSF6 / SRP55

serine/arginine-rich splicing factor 6

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Gene Name: serine/arginine-rich splicing factor 6
Synonyms: SRSF6, B52, Pre-mRNA-splicing factor SRP55, SFRS6, SR splicing factor 6, SRP55
Target Sequences: NM_006275 NP_006266.2 Q13247

Publications (4)

1
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:2366-70. (IP; Mouse) [Full Text Article] [PubMed:23341618] [PMC:PMC3568346] Related Antibodies: LS-B5712.
2
Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Manetti M, Guiducci S, Romano E, Ceccarelli C, Bellando-Randone S, Conforti ML, Ibba-Manneschi L, Matucci-Cerinic M. Circulation research. 2011 109:e14-26. (ELISA; Human) [Full Text Article] [PubMed:21636803]
3
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic ß-cells. Maria Inês Alvelos, Mirko Brüggemann, Fx Reymond Sutandy, Jonàs Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, ngela Castela, Annemieke Aartsma-Rus, Julian König, Kathi Zarnack, Décio L Eizirik. Life science alliance. 2021 March;4: [Full Text Article] [PubMed:33376132] [PMC:PMC7772782] Related Antibodies: LS-C290327.
4
Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Fern[Character e1]ndez-Nogales M, Cabrera JR, Santos-Galindo M, Hoozemans JJ, Ferrer I, Rozemuller AJ, Hern[Character e1]ndez F, Avila J, Lucas JJ. Nature medicine. Aug;20:881-5. [Full Text Article] [PubMed:25038828] Related Antibodies: LS-B5712.
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Proteins (4)
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SRSF6 / SRP55 (4)
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SRSF6 / SRP55 Protein - 12.5% SDS-PAGE of human SFRS6 stained with Coomassie Blue
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Wheat Germ Extract
GST
66 kDa
2 µg/$439
SRSF6 / SRP55 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$150
SRSF6 / SRP55 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$494
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Wheat Germ Extract
GST, N-terminus
25 µg/$670; 10 µg/$479
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).