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SRSF10 / FUSIP1 is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants.
Gene Name: | serine/arginine-rich splicing factor 10 |
Synonyms: | SRSF10, 40 kDa SR-repressor protein, FUSIP1, FUSIP2, Neural-salient SR protein, SFRS13, Splicing factor SRp38, SRrp40, TASR1, TLS-associated protein TASR, TLS-associated SR protein, SFRS13A, TASR, NSSR, SR splicing factor 10, SRp38, TASR2 |
Target Sequences: | NM_006625 NP_006616.1 O75494 |
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