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SRRT / ARS2
serrate RNA effector molecule homolog (Arabidopsis)
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
| Gene Name: | serrate RNA effector molecule homolog (Arabidopsis) |
| Synonyms: | SRRT, Arsenate resistance protein 2, ARS2, Serrate, Arsenite resistance protein, Arsenite-resistance protein 2, ASR2 |
| Target Sequences: | NM_015908 NP_056992.4 Q9BXP5 |
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