SRGAP2

SLIT-ROBO Rho GTPase activating protein 2

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SRGAP2 (3)

Publications

No (3)

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Myc-DDK (Flag) (3)

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Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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Human SRGAP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73110

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.7 kDa

Price:

20 µg/$1,107

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SRGAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113293

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.7 kDa

Price:

100 µg/$710

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Human SRGAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94416

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.7 kDa

Price:

20 µg/$215

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