SRGAP2

SLIT-ROBO Rho GTPase activating protein 2

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

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Antibodies (4)

Type

Primary (4)

Target

SRGAP2 (4)

Reactivity

Human (4)

Mouse (2)

Rat (1)

Hamster (1)

Horse (1)

Monkey (1)

Rabbit (1)

Application

IHC (1)

WB (4)

ELISA (1)

IF (1)

IP (1)

Peptide-ELISA (3)

Host

rabbit (3)

goat (1)

Isotype

IgG (1)

Clonality

polyclonal pc (4)

Format

Unconjugated (4)

Epitope

aa1040-1071 (1)

aa197-210 (1)

aa997-1030 (1)

Publications

No (4)

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SRGAP2 Antibody LS-C752044

Antibody:

SRGAP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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SRGAP2 Antibody (aa197-210) LS-C139575

Antibody:

SRGAP2 Goat anti-Human Polyclonal (aa197-210) Antibody

Reactivity:

Rabbit, Mouse, Rat, Hamster, Horse, Human, Monkey

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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SRGAP2 Antibody (aa1040-1071) LS-C392757

Antibody:

SRGAP2 Rabbit anti-Human Polyclonal (aa1040-1071) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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SRGAP2 Antibody (aa997-1030) LS-C392758

Antibody:

SRGAP2 Rabbit anti-Human Polyclonal (aa997-1030) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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